The Stream Sampling Kit (SSK) holds bachelor’s degree in chemistry with a minor in math and a PhD in physical chemistry from the University of Puerto Rico. Drawing on more than 25 years of experience in the scientific and pharmaceutical fields, he developed an innovative consulting business model to meet companies’ emerging needs. He founded Conde InduServices Corp. in 2010 to offer his expertise to health-related industries and technology development.
Developed and supported by Rodolfo J. Romañach, Ph.D. and Rafael Méndez, Ph.D. from the University of Puerto Rico – Mayagüez Campus, licensed by the Puerto Rico Science, Technology and Research Trust (PRSTRT), and exclusively manufactured by CIS International with the direct support of Dr. Carlos Conde, the SSK is backed by multiple peer-reviewed publications (2020–2024, International Journal of Pharmaceutics).
Traditional sampling methods rely on laboratory testing that is often slow, complex, and prone to biases due to particle behavior. In contrast, the SSK functions as a real-time sampling interface, integrating directly into the process stream and working seamlessly with PAT tools such as NIR and Raman analyzers.
How it Works
Powder flows from a hopper or a continuous mixer to the Stream Sampling Kit
Powder is confined within paddles (designed to eliminate the wave pattern)
NIR, Raman spectra, or other PAT tools monitor quality in real-time
Powder leaves the system, avoiding recirculation (different from what occurs in most feed frames)
The system ensures:
Powder flows from a hopper or a continuous mixer to the Stream Sampling Kit
Powder is confined within paddles (designed to eliminate the wave pattern)
NIR, Raman spectra, or other PAT tools monitor quality in real-time
Powder leaves the system, avoiding recirculation (different from what occurs in most feed frames)
Intended for:
Pharmaceutical manufacturing (batch or continuous) Biopharmaceutical production Powder blending, homogenization, granulation, and compression processes
SSK Benefits:
Enables true real-time quality monitoring and decision-making
Eliminates sampling biases from traditional “thieving” methods Supports faster time to product introduction (great for NPI)
Improves process understanding and knowledge
Strengthens process control and reliability
Avoids particle rearrangement, attrition, and recirculation
Ensures equal sampling probability (Fundamental Sampling Principle)
Works with PAT tools for immediate quality measurement, adjustments, and control
Tested with multiple formulations (e.g., Ibuprofen/Lactose/MCC blends, etc.)
Demonstrated stable NIR spectra during continuous operation
Supported by extensive scientific literature (2020–2024 studies)
Supported by SMEs from the Academia and CIS International
Our Value Proposition
Technical Summary
The stream sampler with an approximate capacity between 8 – 100 kg/h
Wide range of material properties studied (Carr’s Index between 21 and 40)
Wide range of API concentrations (0.7 – 80% w/w)
Easy to clean and small in size
Avoid complex flow dynamics of the feed frame (avoids recirculation)
No need to install NIR or Raman inside the feed frame or use a long fiber optic probe
Adaptability to granulators, blenders, and multiple tablet compression machines, regardless of the feed frame
Variographic analysis – Sampling & Error.
SSK product (equipment)
SSK hardware and components (piping fully customizable, optics, motor, electronics, and sensors)
Supported and compatible with most PAT tools (e.g., NIR, Raman, etc.)
Support with different chemometrics software and data acquisition software
Accessories and
Documents: Installation
Manual, BOM, Designs, URS, IOPQ package, SOP, warranty, etc.
Reference literature
Services
SSK hardware and components (piping fully customizable, optics, motor, electronics, and sensors)
Supported and compatible with most PAT tools (e.g., NIR, Raman, etc.)
Support with different chemometrics software and data acquisition software
Accessories and
Documents: Installation
Manual, BOM, Designs, URS, IOPQ package, SOP, warranty, etc.
Reference literature
Featured Integrations
The SSK is designed for seamless integration across processes and analytical systems:
Process Integration
Continuous mixing and blending
Roller compaction
Granulation and drying
Lubrication and compression
Tablet press operations
Compatible Analyzers:
VIAVI MicroNIR (PAT-U & PAT-W)
Bruker Matrix-F II Process FT-NIR
Sentronic SentroProbe DR LS
Thermo Fisher MARQ Raman
Additional analyzers under testing
Stream Sampling Kit
Real-Time Quality for Pharmaceutical Powders
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Machine Shop
Design 2D and 3D of customized parts
STL and .PDF Conversion Available
Parts are machined using 3D Printing (ABS) and other specific materials
Inspection process according to specifications
Assembly and Packaging
Delivery with Specifications, SDS, Part Lists and Drawings
